The DNHS® technic acts at different levels within the body and produces different effects on the patient.

At a local level, its direct effects are based on the mechanical breakage of dysfunctional motor endplates, which reduces the excessive and therefore abnormal electromyographic activity generated by them.

Although the technique has also been shown to have indirect beneficial effects on the central nervous system, the mechanism of action is unclear. Researcher Dr. Pablo Herrero reports in his first publication of the DNHS® to the local twitch response and its relation with the central nervous system as a possible hypothesis of the observed changes in hypertonia and spasticity. The most recent investigations have not allowed to confirm this hypothesis, but they show evidences of changes in the processing of the sensorimotor information at upper levels of the CNS measured with electroencephalography.