The DNHS® technique acts upon different levels within the body and has different effects on the patient.
The direct effects are based on destroying the dysfunctional endplates, thereby decreasing the excessive and therefore abnormal electromyographical activity generated by these.
Although the technique has been shown to have indirect benefits for the central nervous system, the mechanism for this is not clear. According to the author of this technique in the first DNHS® technique publication, the connection with the central nervous system is cited as a possible cause for the observed changes in hypertonia and spasticity. The most recent research has failed to confirm this hypothesis, but shows evidence of changes in central processing of sensorimotor information in the brain as measured by electroencephalography.